17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

Cloud-Clone

S430

PubMed

The mouse 17aHSD is the unique known member of the aldo-keto reductase (AKR) superfamily able to catalyze efficiently and in a stereospecific manner the conversion of androstenedione (Delta4) into epi-testosterone (epi-T), the 17alpha-epimer of testosterone. Structural and mutagenic studies had already identified one of the residues delineating the steroid-binding cavity, A24, as the major molecular determinant for the stereospecificity of m17alpha-HSD. Indeed, in addition to the interactions found in all other AKRs, m17alpha-HSD establishes with the other extremity of the steroid nucleus an additional interaction involving K31. Mutagenesis and structural studies made on the human type 3 3alpha-HSD, a closely related enzyme that shares 73% amino acids identity with the m17alpha-HSD, the residue at position 24 of these two enzymes directly affects the binding and/or the release of NADPH, in addition to its role in their 17alpha/17beta stereospecificity.

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Sandwich ELISA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

Организм:

Человек

Артикул:

SES430Hu

Sandwich ELISA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

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Уточнить

Sandwich ELISA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

Организм:

Мышь

Артикул:

SES430Mu

Sandwich ELISA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

В наличии:

Уточнить

Организм

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Sandwich CLIA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

Организм:

Человек

Артикул:

SCS430Hu

Sandwich CLIA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

В наличии:

Уточнить

Sandwich CLIA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

Организм:

Мышь

Артикул:

SCS430Mu

Sandwich CLIA for 17-Alpha-Hydroxysteroid Dehydrogenase (HSD17a)

В наличии:

Уточнить

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