A Disintegrin And Metalloprotease 5 (ADAM5)

HUGO

212

MGI

104730

UniProt

Q6NVV9

Cloud-Clone

S446

RGD

621471

Five members of the MDC family of proteins (fertilin alpha, fertilin beta, tMDC I, tMDC II and tMDC III) are expressed on the surface of macaque sperm, where they have been proposed to play a role in sperm-egg binding via an interaction between their disintegrin-like domain and one or more integrins on the egg plasma membrane. Of these, two (fertilin alpha and tMDC I) have recently been shown to be non-functional in the human. The existence of multiple isoforms of human tMDC II transcripts in the human, all of which are also non-functional owing to the presence of deletions and in-frame termination codons, when compared with the macaque orthologue, a finding which is further supported by the lack of immunoreactivity on Western blots of human testis and sperm extracts probed with a macaque anti-tMDC II polyclonal antiserum.

Организм

Артикул

Наименование

В наличии

Polyclonal Antibody to A Disintegrin And Metalloprotease 5 (ADAM5)

Применение:

вестерн-блот; иммуногистохимия; иммуноцитохимия; иммунопреципитация.

Организм:

Крыса

Артикул:

PAS446Ra01

Polyclonal Antibody to A Disintegrin And Metalloprotease 5 (ADAM5)