BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

HUGO

UniProt

Cloud-Clone

M599

The deduced 108-amino acid protein has a calculated molecular mass of about 12 kD. The N terminus contains a domain similar to the BH3 domain of proapoptotic proteins. Western blot analysis detected endogenous BRCC2 in all human cell lines tested. In COS-1 and HeLa cells, BRCC2 was predominantly a cytosolic protein, with lower abundance in mitochondria.In a human prostate cancer cell line, BRCC2-induced DNA fragmentation was blocked by coexpression of the antiapoptotic molecule BCLXL or by a broad-range caspase inhibitor. BRCC2 expression correlated with activation of CASP3 and CASP9. BRCC2 with an N-terminal deletion of the BH3-like domain failed to induce apoptosis. Treatment of HeLa cells with doxorubicin or hydrogen peroxide led to an increase in the mitochondrial level of endogenous BRCC2.

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Sandwich ELISA for BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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Человек

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SEM599Hu

Sandwich ELISA for BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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Sandwich CLIA for BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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Человек

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SCM599Hu

Sandwich CLIA for BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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Polyclonal Antibody to BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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Человек

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PAM599Hu01

Polyclonal Antibody to BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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Monoclonal Antibody to BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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MAM599Hu21

Monoclonal Antibody to BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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Recombinant protein BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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RPM599Hu01

Recombinant protein BH3-Like Motif Containing Protein, Cell Death Inducer (BLID)

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